帕金森病的呼吸变化可能与多巴胺能功能障碍无关。
Respiratory changes in Parkinson's disease may be unrelated to dopaminergic dysfunction.
作者信息
Guedes Luciana Ulhôa, Rodrigues Juliana Melo, Fernandes Aline Andrioni, Cardoso Francisco E, Parreira Verônica Franco
机构信息
Rehabilitation Science Graduation Program, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, MG, Brazil.
出版信息
Arq Neuropsiquiatr. 2012 Nov;70(11):847-51. doi: 10.1590/s0004-282x2012001100005.
OBJECTIVE
To investigate the maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in patients with Parkinson's disease (PD) during the on and off periods of levodopa and to compare with healthy controls.
METHODS
Twenty-six patients were analyzed with Hoehn and Yahr scores (2-3) and 26 age and gender matched-controls. Statistical analysis was performed with Student's t-test for paired and independent samples.
RESULTS
MIP and MEP values in patients were significantly lower than the values obtained in controls both for off and on stages -excepted for MIP in women (p=0.28). For patients with PD, the studied parameters did not differ between stages on and off, with the exception of MEP in women (p=0.00).
CONCLUSIONS
Patients with PD have respiratory pressure lower than controls, even in early stages of the disease, and dopamine replacement has little impact over these respiratory pressures. These findings suggest that respiratory changes in PD may be unrelated to dopaminergic dysfunction.
目的
研究帕金森病（PD）患者在左旋多巴开启期和关闭期的最大吸气压（MIP）和最大呼气压（MEP），并与健康对照者进行比较。
方法
对26例 Hoehn 和 Yahr 评分（2 - 3）的患者以及26例年龄和性别匹配的对照者进行分析。采用配对和独立样本的 Student t 检验进行统计分析。
结果
除女性的 MIP 外（p = 0.28），患者在关闭期和开启期的 MIP 和 MEP 值均显著低于对照组。对于帕金森病患者，除女性的 MEP 外（p = 0.00），研究参数在开启期和关闭期之间无差异。
结论
帕金森病患者即使在疾病早期呼吸压力也低于对照组，多巴胺替代对这些呼吸压力影响不大。这些发现表明帕金森病的呼吸变化可能与多巴胺能功能障碍无关。
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