HIV-1 Vif 介导的 APOBEC3G 降解和核心结合因子 β介导的 RUNX1 转录的差异需求。
Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta.
机构信息
Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China.
出版信息
J Virol. 2013 Feb;87(3):1906-11. doi: 10.1128/JVI.02199-12. Epub 2012 Nov 21.
Abstract
Core binding factor beta (CBFβ), a transcription regulator through RUNX binding, was recently reported critical for Vif function. Here, we mapped the primary functional domain important for Vif function to amino acids 15 to 126 of CBFβ. We also revealed that different lengths and regions are required for CBFβ to assist Vif or RUNX. The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors.
摘要
核心结合因子β（CBFβ）是一种通过与 RUNX 结合而发挥转录调控作用的蛋白，最近有报道称其对 Vif 功能至关重要。在此，我们将 Vif 功能所必需的主要功能域定位到 CBFβ的 15 至 126 个氨基酸。我们还揭示了不同长度和区域对于 CBFβ辅助 Vif 或 RUNX 是必需的。对于 Vif 功能而不是 RUNX 功能所必需的独特重要相互作用域代表了开发 HIV 抑制剂的新靶标。
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