Fenton J, Chevret S, Asselain B, de La Rochefordière A, Mathieu G, Labib A, Durand J C, Salmon R J
Service de radiothérapie A, Institut Curie, Paris, France.
Bull Cancer. 1990;77(2):109-16.
The study of cases treated between 1970 and 1984 at the Institut Curie, in women aged 40 years and under, was undertaken in order to determine the influence of age on prognosis. The incidence of these cases was stable throughout the 15 years study period as was the very high incidence of earlier cases: 84.5%. Earlier cases were treated with combined radiotherapy and surgery and advanced cases with radiotherapy alone. Overall survival rate was 75% at 5 years, 60% at 10 and 15 years: but 85% for the 36-40 years of age group, 74% for the 30-35 years of age group and 67% for women aged 29 and less. Five year survival rate for operated cases is the same for the 36-40 age group as for all age patients, according to the lymph node status. In contrast, it was 85% in the N-younger group, and 30% for those patients with lymph node involvement. In conclusion, from our study it appears that the overall survival rate for women of 36 years and less, and mainly 29 years and less, is significantly lower than that for older women, and that their prognosis is especially poor in the case of lymph node involvement.
为了确定年龄对预后的影响，我们对1970年至1984年期间在居里研究所接受治疗的40岁及以下女性病例进行了研究。在整个15年的研究期间，这些病例的发病率保持稳定，早期病例的发病率也非常高：84.5%。早期病例采用放疗和手术联合治疗，晚期病例仅采用放疗。5年总生存率为75%，10年和15年分别为60%：但36 - 40岁年龄组为85%，30 - 35岁年龄组为74%，29岁及以下女性为67%。根据淋巴结状况，36 - 40岁年龄组手术病例的5年生存率与所有年龄患者相同。相比之下，N-年轻组为85%，有淋巴结受累的患者为30%。总之，从我们的研究来看，36岁及以下女性，主要是29岁及以下女性的总生存率明显低于老年女性，而且在有淋巴结受累的情况下，她们的预后尤其差。
