Murphy R G, Greenberg M L
Department of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
Cancer. 1990 Apr 15;65(8):1717-21. doi: 10.1002/1097-0142(19900415)65:8<1717::aid-cncr2820650809>3.0.co;2-b.
The authors report five pediatric patients with acute lymphoblastic leukemia (ALL) in whom symptomatic aseptic osteonecrosis developed on therapy. All patients had been on treatment with a modified BFM protocol and developed osteonecrosis in the maintenance phase of the protocol. The avascular necrosis was multifocal in all. The authors' data suggest that dexamethasone used in the reinduction phase of the protocol may be the responsible agent although no definite proof exists. Since only symptomatic patients are reported, the true frequency of this complication may be significantly higher.
作者报告了5例急性淋巴细胞白血病（ALL）患儿，他们在治疗过程中出现了有症状的无菌性骨坏死。所有患者均采用改良的BFM方案进行治疗，并在该方案的维持期发生了骨坏死。所有患者的缺血性坏死均为多灶性。作者的数据表明，该方案再诱导期使用的地塞米松可能是致病因素，尽管尚无确切证据。由于仅报告了有症状的患者，因此这种并发症的实际发生率可能显著更高。
