Mazeron R, Bajard A, Pommier P
Service de curiethérapie, département de radiothérapie, institut de cancérologie Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France.
Cancer Radiother. 2012 Dec;16(8):702-10; quiz 722, 725. doi: 10.1016/j.canrad.2012.09.004. Epub 2012 Nov 22.
Permanent seeds brachytherapy is a standard in the treatment of localized prostate cancer. Follow-up of patients treated with brachytherapy relies on monitoring the concentration of PSA. It is supposed to decrease steadily to a nadir after several years. This decrease could be disrupted by transient and benign elevation of the marker, sometimes mimicking genuine biochemical relapses, sources of anxiety for patients or even unnecessary tests. While the precise mechanisms of this phenomenon are poorly understood, their characteristics have been, however, extensively studied. This work aims to make an update on the current state of knowledge.
永久性种子近距离放射治疗是局限性前列腺癌治疗的标准方法。接受近距离放射治疗患者的随访依赖于监测前列腺特异性抗原（PSA）的浓度。PSA浓度在数年后应稳步下降至最低点。该标志物的短暂性和良性升高可能会干扰这种下降，有时会模拟真正的生化复发，给患者带来焦虑甚至导致不必要的检查。虽然对这一现象的确切机制了解甚少，但对其特征已进行了广泛研究。这项工作旨在对当前的知识状况进行更新。
