miR-137 通过靶向 Cdc42 和 Cdk6 抑制肺癌细胞的增殖。
miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6.
机构信息
The Fourth Affiliated Hospital of Jiangsu University, 20 Zhengdong Road, Zhenjiang, Jiangsu 212000, China.
出版信息
FEBS Lett. 2013 Jan 4;587(1):73-81. doi: 10.1016/j.febslet.2012.11.004. Epub 2012 Nov 21.
MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in lung cancer cells could be rescued following inhibition of DNA methylation. Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease in cell growth in vivo and in vitro. Further, both Cdc42 and Cdk6 were confirmed as targets of miR-137.
MicroRNAs (miRNA) 已成为癌症发生的关键因素。在这里，我们研究了 miR-137 在肺癌发病机制中的作用。肺癌细胞中 miR-137 的下调可以通过抑制 DNA 甲基化得到挽救。在肺癌细胞中异位表达 miR-137 显著下调了 Cdc42、Cdk6，并诱导 G1 细胞周期停滞，导致体内和体外细胞生长显著减少。此外，Cdc42 和 Cdk6 均被确认为 miR-137 的靶标。
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