Fariha Atqiya, Hami Ithmam, Tonmoy Mahafujul Islam Quadery, Akter Shahana, Al Reza Hasan, Bahadur Newaz Mohammed, Rahaman Md Mizanur, Hossain Md Shahadat
Department of Biotechnology & Genetic Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh.
Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.
Heliyon. 2022 Oct 13;8(10):e11081. doi: 10.1016/j.heliyon.2022.e11081. eCollection 2022 Oct.
Lung cancer is the primary cause of cancer related deaths worldwide. Limited therapeutic options and resistance to existing drugs are the major hindrances to the clinical success of this cancer. In the past decade, several studies showed the role of microRNA (miRNA) driven cell cycle regulation in lung cancer progression. Therefore, these small nucleotide molecules could be utilized as promising tools in lung cancer therapy. In this review, we highlighted the recent advancements in lung cancer therapy using cell cycle linked miRNAs. By highlighting the roles of the specific cell cycle core regulators affiliated miRNAs in lung cancer, we further outlined how these miRNAs can be explored in early diagnosis and treatment strategies to prevent lung cancer. With the provided information from our review, more medical efforts can ensure a potential breakthrough in miRNA-based lung cancer therapy.
肺癌是全球癌症相关死亡的主要原因。有限的治疗选择和对现有药物的耐药性是这种癌症临床治疗成功的主要障碍。在过去十年中，多项研究表明微小RNA（miRNA）驱动的细胞周期调控在肺癌进展中的作用。因此，这些小分子核苷酸可作为肺癌治疗中有前景的工具。在本综述中，我们重点介绍了利用与细胞周期相关的miRNA进行肺癌治疗的最新进展。通过强调特定细胞周期核心调节因子相关miRNA在肺癌中的作用，我们进一步概述了如何在早期诊断和治疗策略中探索这些miRNA以预防肺癌。根据我们综述提供的信息，更多的医学努力可以确保基于miRNA的肺癌治疗取得潜在突破。
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