Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA.
Cancer Lett. 2013 Nov 1;340(2):241-6. doi: 10.1016/j.canlet.2012.11.029. Epub 2012 Nov 20.
Gastric cancer is the second most common cause of cancer-related death in the world, representing a major global health issue. The high mortality rate is largely due to the lack of effective medical treatment for advanced stages of this disease. Recently next-generation sequencing (NGS) technology has become a revolutionary tool for cancer research, and several NGS studies in gastric cancer have been published. Here we review the insights gained from these studies regarding how use NGS to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets. We also discuss the challenges and future directions of such efforts.
胃癌是全球第二大癌症相关死亡原因,是一个全球性的重大健康问题。高死亡率主要归因于对该疾病晚期缺乏有效的医疗手段。最近,下一代测序(NGS)技术已成为癌症研究的革命性工具,已经有几项关于胃癌的 NGS 研究发表。在这里,我们回顾了这些研究中获得的见解,即如何利用 NGS 阐明胃癌的分子基础并确定潜在的治疗靶点。我们还讨论了这些努力所面临的挑战和未来方向。