Wolter M, Marsch W C
Abteilung I, Universität Frankfurt/Main.
Dtsch Med Wochenschr. 1990 Mar 23;115(12):452-5. doi: 10.1055/s-2008-1065029.
Acute, painful, persisting, pampiniform and asymmetrical skin discolorations over the legs occurred after retrograde femoral artery catheterization in three patients suspected of having renal artery stenosis. The cause was found histologically to be embolization of cholesterol crystals to the arterioles of the corium-subcutis. Under treatment with acetylsalicylic acid the painful cutaneous changes gradually regressed. The possibility of cholesterol crystal emboli from atheromatous plaques in the aorta should be considered if the described skin changes occur, especially in the legs and with normal arterial pulsations. Proof lies in the histological picture of slit-like spaces in the arteriolar vessels at the corium-subcutis juncture, previously occupied by cholesterol crystals dissolved during fixation, and surrounding inflammatory changes with vessel wall thickening.
三名疑似肾动脉狭窄的患者在逆行股动脉插管后,腿部出现急性、疼痛性、持续性、蔓状且不对称的皮肤变色。组织学检查发现病因是胆固醇结晶栓塞至真皮 - 皮下组织的小动脉。在阿司匹林治疗下,疼痛性皮肤改变逐渐消退。如果出现上述皮肤改变,尤其是在腿部且动脉搏动正常时,应考虑主动脉粥样斑块中胆固醇结晶栓子的可能性。证据在于真皮 - 皮下组织交界处小动脉血管中呈裂隙状空间的组织学图像,这些空间先前被固定过程中溶解的胆固醇结晶占据,以及周围伴有血管壁增厚的炎症改变。