Korchenko V A, Il'nitskiĭ A P, Ermilov V B, Mistakopulo G M, Nechipaĭ A M
Eksp Onkol. 1990;12(2):24-6.
It has been shown in vitro with human acidic gastric juice the nitrosomorpholine (NMOR) formation from small doses of precursors (sodium nitrite and morpholine) with a significant difference relative to the control. The presented data suggest the possibility of the nitrosation reaction in the human gastric juice under hypo- and anacidic conditions. The data obtained are one more experimental confirmation of the epidemiological evidence of the potential role of nitrates (nitrites) in the etiology of stomach and esophageal cancers.
在体外实验中已表明,在人体酸性胃液中,小剂量前体物质(亚硝酸钠和吗啉)可形成亚硝基吗啉(NMOR),与对照组相比有显著差异。所呈现的数据表明,在胃酸过少和无酸条件下,人体胃液中存在亚硝化反应的可能性。获得的数据进一步实验证实了硝酸盐(亚硝酸盐)在胃癌和食管癌病因学中潜在作用的流行病学证据。