Ermilov V B, Shendrikova I A, Volkov D P, Stefanenko Iu F, Chernomordikov V G
Vopr Onkol. 1986;32(10):58-64.
The paper discusses the effect of vitamins C and E and Plantaglucide on nitroso compounds yield in the course of nitrosation of amines in human gastric juice. The study group included 56 subjects. The above drugs capable of inhibiting in vitro nitrosation produced an anomalous effect in gastric juice of some subjects, i.e. potentiated nitroso compounds yield in nitrosation of amines by sodium nitrite. The said action of vitamins C and E was apparent in dimethylamine and amidopyrine nitrosation but it was not in morpholine nitrosation. Sharply increased levels in nitroso compounds were observed in some mice fed precursors of nitroso compounds in combination with vitamin C and Plantaglucide. These data point to an anomalous effect of the drugs on the body.
本文讨论了维生素C、维生素E和Plantaglucide对人胃液中胺类亚硝化过程中亚硝基化合物产量的影响。研究组包括56名受试者。上述能够在体外抑制亚硝化作用的药物，在一些受试者的胃液中产生了反常效应，即在亚硝酸钠使胺类亚硝化过程中，亚硝基化合物产量增加。维生素C和维生素E的上述作用在二甲胺和氨基比林亚硝化过程中明显，但在吗啉亚硝化过程中则不明显。在一些给亚硝基化合物前体与维生素C和Plantaglucide组合喂食的小鼠中，观察到亚硝基化合物水平急剧升高。这些数据表明这些药物对机体有反常效应。
