Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.
Diabetes Obes Metab. 2013 May;15(5):474-7. doi: 10.1111/dom.12043. Epub 2012 Dec 17.
Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation. We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.
胰高血糖素样肽-1（GLP-1）和肽 YY（PYY）由分布在结肠和直肠的肠内分泌 L 细胞分泌，对于血糖和食欲调节具有重要意义。在动物模型中，胆汁酸通过 TGR5 受体激活可刺激 GLP-1 和 PYY 的分泌。我们评估了通过灌肠给予牛磺胆酸（TCA）对 10 名健康男性受试者血浆 GLP-1 和 PYY 以及胃肠道感觉的影响，结果发现 TCA 直肠给药可迅速刺激 GLP-1 和 PYY 的分泌，并以剂量依赖的方式增加饱腹感。这些观察结果证实，将胆汁酸局部应用于远端肠道可能有潜力用于治疗 2 型糖尿病和肥胖症。
