Delévaux I, Chamoux A, Aumaître O
Service de médecine interne, CHU de Clermont-Ferrand, 58 rue Montalembert, Clermont-Ferrand cedex 1, France.
Rev Med Interne. 2013 Aug;34(8):487-92. doi: 10.1016/j.revmed.2012.10.366. Epub 2012 Nov 20.
The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Stress impairs cellular immunity, decreases immune tolerance and stimulates humoral immunity exposing individuals to autoimmune disease among others. The treatment for autoimmune disease should include stress management.
自身免疫性疾病的病因是多因素的。压力可能是一个参与因素。事实上，很大一部分自身免疫性疾病患者在疾病发作或病情加重之前报告有异常压力。压力的生物学后果越来越为人所知。应激期间下丘脑 - 垂体 - 肾上腺轴释放的糖皮质激素和儿茶酚胺会改变Th1/Th2平衡以及Th17/Treg平衡。压力会损害细胞免疫，降低免疫耐受性并刺激体液免疫，使个体易患自身免疫性疾病等。自身免疫性疾病的治疗应包括压力管理。
