Reproductive Medicine Research Center, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong, China.
Reprod Biomed Online. 2013 Jan;26(1):30-5. doi: 10.1016/j.rbmo.2012.10.004. Epub 2012 Oct 12.
The purpose of this study was to evaluate the effect of sequential embryo transfer in patients with repeated IVF failure. A retrospective matched case-control study was conducted and the outcomes of 213 patients with a history of repeated IVF-embryo transfer failure were analysed, of which 33 women underwent sequential embryo transfer on day 2 and day 3 (D2/D3 group), 66 women on day 3 and day 5 (D3/D5 group), 85 women underwent day-3 embryo transfer only (D3 control group) and 29 women underwent day-5 embryo transfer only (D5 control group) in the assisted reproduction centre of the Sixth Affiliated Hospital of Sun Yat-sen University from August 2010 to December 2011. The results showed that the clinical pregnancy rate of the D2/D3 group was higher than that of the D3 group (48.5% versus 22.4%, P=0.006) while the clinical pregnancy rates of the D3/D5 and D5 groups were not significantly different (50.9% versus 45.8%). Day-2 and day-3 sequential embryo transfer may improve the clinical outcomes for patients with repeated IVF-embryo transfer failures. The purpose of this study was to evaluate the effect of sequential embryo transfer in patients with repeated IVF failure. A retrospective matched case-control study was conducted and the outcomes of 213 patients with a history of repeated IVF-embryo transfer failure were analysed, of which 33 women underwent sequential embryo transfer on day 2 and day 3 (D2/D3 group), 66 women on day 3 and day 5 (D3/D5 group), 85 women underwent day-3 embryo transfer only (D3 control group) and 29 women underwent day-5 embryo transfer only (D5 control group) in the assisted reproduction centre of the Sixth Affiliated Hospital of Sun Yat-sen University from August 2010 to December 2011. The results showed that the clinical pregnancy rate of the D2/D3 group was higher than that of the D3 group (48.5% versus 22.4%, P=0.006) while the clinical pregnancy rates of the D3/D5 and D5 groups were not significantly different (50.9% versus 45.8%). Day-2 and day-3 sequential embryo transfer may improve the clinical outcomes for patients with repeated IVF-embryo transfer failures.
本研究旨在评估反复体外受精失败患者序贯胚胎移植的效果。采用回顾性匹配病例对照研究，分析 2010 年 8 月至 2011 年 12 月中山大学附属第六医院辅助生殖中心 213 例反复体外受精-胚胎移植失败患者的结局，其中 33 例于第 2 天和第 3 天行序贯胚胎移植（D2/D3 组），66 例于第 3 天和第 5 天行序贯胚胎移植（D3/D5 组），85 例仅行第 3 天胚胎移植（D3 对照组），29 例仅行第 5 天胚胎移植（D5 对照组）。结果显示，D2/D3 组临床妊娠率高于 D3 组（48.5%比 22.4%，P=0.006），D3/D5 组与 D5 组临床妊娠率无显著差异（50.9%比 45.8%）。D2 和 D3 天序贯胚胎移植可能改善反复体外受精-胚胎移植失败患者的临床结局。
