Hanssen S, Collinet P, Leblanc E, Salzet M, Vinatier D
Service de chirurgie gynécologique, hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille cedex, France.
J Gynecol Obstet Biol Reprod (Paris). 2013 May;42(3):217-26. doi: 10.1016/j.jgyn.2012.10.007. Epub 2012 Nov 22.
During pregnancy an environment allowing installation of tolerance toward the fetus is set up locally at the materno-fetal interface. Numerous effectors of immunity are involved in this tolerance (NK cell, T cell, Macrophages, dendritic cell). Specific mechanisms during pregnancy attract locally these immunological cells. In the decidua, they are educated toward tolerance. These mechanisms evolve during the pregnancy because at the end of the pregnancy, tolerance is broken to prepare and activate the labor. Ovarian tumors, after having surmounted the immunosurveillance, like trophoblast, chair the installation of a tolerance of their host facilitating the development of the disease. The blocking of these mechanisms of tolerance coupled with activation of mechanisms of defenses offer new perspectives in the treatment of the ovarian cancer. The authors suggest showing the analogies of the tolerance observed during ovarian cancer and pregnancy. The knowledge of the orchestration of the physiological mechanisms observed during pregnancy will offer new therapeutic targets.
在怀孕期间，母体-胎儿界面会局部建立起一种允许对胎儿产生耐受性的环境。多种免疫效应细胞参与了这种耐受性（自然杀伤细胞、T细胞、巨噬细胞、树突状细胞）。孕期的特定机制会在局部吸引这些免疫细胞。在蜕膜中，它们被诱导产生耐受性。这些机制在孕期会发生演变，因为在妊娠末期，耐受性会被打破以准备并启动分娩。卵巢肿瘤在克服免疫监视后，如同滋养层细胞一样，会在宿主中建立一种耐受性，从而促进疾病的发展。阻断这些耐受性机制并激活防御机制为卵巢癌的治疗提供了新的视角。作者建议展示卵巢癌和孕期所观察到的耐受性之间的相似之处。了解孕期所观察到的生理机制的协调作用将提供新的治疗靶点。
