基底核损伤不会在大鼠中诱发老年斑。
Nucleus basalis lesions fail to induce senile plaques in the rat.
作者信息
Thal L J, Mandel R J, Terry R D, Buzsaki G, Gage F H
机构信息
Neurology Service, VA Medical Center, San Diego, California 92161.
出版信息
Exp Neurol. 1990 Apr;108(1):88-90. doi: 10.1016/0014-4886(90)90013-i.
PMID:2318291
Abstract
Fourteen months after receiving bilateral ibotenic acid lesions of the nucleus basalis magnocellaris (NBM), male rats demonstrated impairment in spatial learning in a water maze task, increased incidence of high voltage spindles, and significant depletion of cortical choline acetyltransferase (ChAT) activity. Histological evaluation revealed decreased acetylcholinesterase (AChE) staining but no plaque-like structures in the cortex.
摘要
在接受双侧大细胞基底核（NBM）鹅膏蕈氨酸损伤14个月后，雄性大鼠在水迷宫任务中表现出空间学习能力受损、高压纺锤波发生率增加以及皮质胆碱乙酰转移酶（ChAT）活性显著降低。组织学评估显示皮质中乙酰胆碱酯酶（AChE）染色减少，但无斑块样结构。
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