Lagrue G, Hirbec G
Sem Hop. 1979;55(35-36):1601-5.
Chronic Glomerulo-Nephritis (GN) are among nephrologic diseases, frequent and severe. In most of them immunological process are involved. Non steroïdal antiinflammatory drugs are able to reduce proteinuria, mainly in Membrano-Proliferative GN and IgA Mesengial GN. A protracted administration is necessary for proteinuria reappeared when treatment is interrupted. With long term administration renal prognosis is improved and severe renal insufficiency delayed. Among active antiinflammatory drugs (indometacine, ketoprofen, diclofenac, flurbiprofen, etc.) diclofenac is one of the best tolerated.
慢性肾小球肾炎（GN）是常见且严重的肾脏疾病之一。其中大多数都涉及免疫过程。非甾体类抗炎药能够减少蛋白尿，主要是在膜增生性肾小球肾炎和IgA系膜增生性肾小球肾炎中。当治疗中断时，蛋白尿再次出现，需要长期给药。长期给药可改善肾脏预后并延缓严重肾功能不全的发生。在活性抗炎药物（吲哚美辛、酮洛芬、双氯芬酸、氟比洛芬等）中，双氯芬酸是耐受性最好的药物之一。
