Acosta A A, Oehninger S, Hammer J, Muasher S J, Liang H M, Jones D L
Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
Fertil Steril. 1990 Apr;53(4):673-6. doi: 10.1016/s0015-0282(16)53462-1.
Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.
辅助生殖中临床前流产的临床及预后意义尚不明确。严格的诊断标准包括在注射人绒毛膜促性腺激素（hCG）13天后血清β-人绒毛膜促性腺激素（hCG）、雌二醇和孕酮水平短暂且同步升高，并在月经推迟后不超过14天出现出血情况。将临床前流产研究组（54例患者，178个周期）与匹配的对照组A（54例患者，132个周期）和对照组B（54例患者，155个周期）进行比较，对照组A和B分别代表足月正常妊娠和所有妊娠结局。对照组C包括研究期间的总体人群。研究组每次移植的流产率（临床前流产率和总流产率）及总妊娠丢失率显著更高；持续妊娠率显著更低。临床前流产应被视为具有相似影响的真正生殖失败。
