Dlouha Dana, Pitha Jan, Adámkova Vera, Lanska Vera, Hubacek Jaroslav A
Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Neuro Endocrinol Lett. 2012;33 Suppl 2:13-6.
Atherosclerosis is a complex arterial disease involving interactions between multiple genetic and environmental factors. A large number of genetic polymorphisms associated with atherosclerotic diseases have been identified in recent years. We investigated the possible association between hepatic nuclear factor (HNF1-α) and angiopoietin-like 4 (ANGPTL4) single nucleotide polymorphisms and the risk of acute coronary syndrome (ACS) in the Czech population.
A total of 1,182 patients with ACS (835 males and 347 females) and 1,200 healthy controls (827 males and 373 females) were included in the study. All patients were younger than 65 years of age. rs7310409 (A>G within the HNF1-α gene) and rs116843064 (G>A within the ANGPTL4 gene) were genotyped using TaqMan genotyping assays.
The frequencies of the genotypes in patients with ACS did not significantly differ from the control group for the rs7310409 polymorphism (AA=17.1%, AG=46.6%, GG=36.2% vs. AA=14.4%, AG=50.3%, GG=35.3%, respectively; p=0.12) or the rs116843064 polymorphism (AA=0.1%, AG=3.5%, GG=96.4% vs. AA=0.1%, AG=4.2%, GG=95.7%, respectively; p=0.69). There was no interaction with gender. In addition, gene variants were not associated with common cardiovascular risk factors (dyslipidaemia, hypertension, smoking, obesity and diabetes).
No association was observed between polymorphisms within the HNF1-α and ANGPTL4 genes and the risk of ACS in the Czech population.
动脉粥样硬化是一种复杂的动脉疾病，涉及多种遗传和环境因素之间的相互作用。近年来，已鉴定出大量与动脉粥样硬化疾病相关的基因多态性。我们研究了肝细胞核因子（HNF1-α）和血管生成素样4（ANGPTL4）单核苷酸多态性与捷克人群急性冠状动脉综合征（ACS）风险之间的可能关联。
本研究共纳入1182例ACS患者（男性835例，女性347例）和1200例健康对照者（男性827例，女性373例）。所有患者年龄均小于65岁。使用TaqMan基因分型检测对rs7310409（HNF1-α基因内A>G）和rs116843064（ANGPTL4基因内G>A）进行基因分型。
对于rs7310409多态性，ACS患者的基因型频率与对照组无显著差异（AA=17.1%，AG=46.6%，GG=36.2%，对照组分别为AA=14.4%，AG=50.3%，GG=35.3%；p=0.12），对于rs116843064多态性亦无显著差异（AA=0.1%，AG=3.5%，GG=96.4%，对照组分别为AA=0.1%，AG=4.2%，GG=95.7%；p=0.69）。不存在与性别的相互作用。此外，基因变异与常见心血管危险因素（血脂异常、高血压、吸烟、肥胖和糖尿病）无关。
在捷克人群中，未观察到HNF1-α和ANGPTL4基因内的多态性与ACS风险之间存在关联。
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