Division of Mechanics, Department of Management and Engineering, The Institute of Technology, Linköping University, 581 83 , Linköping, Sweden,
Biomech Model Mechanobiol. 2013 Oct;12(5):965-73. doi: 10.1007/s10237-012-0456-x. Epub 2012 Nov 25.
The contractile force in skeletal muscle models is commonly postulated to be the isometric force multiplied by a set of experimentally motivated functions which account for the muscle's active properties. Although both flexible and simple, this approach does not automatically guarantee a thermodynamically consistent behavior. In contrast, the continuum mechanical model proposed herein is derived from fundamental principles in mechanics and guarantees a dissipative behavior. Further, the contractile force is associated with a friction clutch which provides a simple and well-defined macroscopic model for cycling cross-bridges. To show the performance of the model, it is specialized to standard experiments for rabbit tibialis anterior muscle. The results show that the model is able to capture important characteristics of skeletal muscle.
骨骼肌模型中的收缩力通常被假定为等长力乘以一组用于解释肌肉主动特性的实验驱动函数。虽然这种方法灵活且简单，但它并不能自动保证热力学一致性。相比之下，本文提出的连续力学模型源自力学的基本原理，保证了耗散行为。此外，收缩力与摩擦离合器相关联，为循环交联桥提供了一个简单且明确定义的宏观模型。为了展示模型的性能，将其专门用于兔胫骨前肌的标准实验。结果表明，该模型能够捕捉到骨骼肌的重要特征。
