Epstein F H
Yale J Biol Med. 1979 Nov-Dec;52(6):517-23.
The rectal gland of the spiny dogfish, Squalus acanthias, provides an easily studied model of active chloride transport powered indirectly by Na-K-ATPase. Co-transport of sodium with chloride can be demonstrated in membrane vesicles isolated from basolateral membranes of the gland. Chloride secretion is under the hormonal control of vasoactive intestinal peptide, and possibly other agents, via adenyl cyclase and cyclic AMP. A similar mechanism is probably responsible for the active transport of chloride across other biological membranes.
棘鲨(Squalus acanthias)的直肠腺提供了一个易于研究的、由钠钾ATP酶间接驱动的主动氯转运模型。钠与氯的协同转运可在从该腺基底外侧膜分离出的膜囊泡中得到证实。氯的分泌受血管活性肠肽以及可能的其他因子通过腺苷酸环化酶和环磷酸腺苷的激素控制。类似的机制可能负责氯在其他生物膜上的主动转运。