Girling A C, Hanby A M, Millis R R
Imperial Cancer Research Fund, Department of Clinical Oncology, Guy's Hospital, London.
J Clin Pathol. 1990 Feb;43(2):152-6. doi: 10.1136/jcp.43.2.152.
Histological changes in breast tissue after radiotherapy were evaluated. Changes in tissue from 17 patients previously treated for breast cancer by surgery and radiotherapy were compared with those seen in a control group treated with surgery alone. Vascular and epithelial changes were seen only in tissue from patients who had received radiotherapy and, therefore, seemed to be relatively specific; stromal changes were seen in both groups and seemed, therefore, to be non-specific. Epithelial atypia is of particular importance as it may be severe and be confused with recurrent malignancy. The presence of other changes associated with radiotherapy, particularly those in vessels, should help to avoid such misdiagnosis.
对放疗后乳腺组织的组织学变化进行了评估。将17例先前接受过乳腺癌手术和放疗的患者的组织变化与仅接受手术治疗的对照组的组织变化进行了比较。血管和上皮变化仅在接受过放疗的患者组织中可见，因此似乎具有相对特异性；两组均可见基质变化，因此似乎是非特异性的。上皮异型性尤为重要，因为它可能很严重，且可能与复发性恶性肿瘤相混淆。与放疗相关的其他变化的存在，尤其是血管中的变化，应有助于避免这种误诊。
