DiNicolantonio James J
Wegmans Pharmacy, 500 South Meadow Street Ithaca, Ithaca, NY 14850, USA.
Expert Rev Cardiovasc Ther. 2012 Oct;10(10):1329-33. doi: 10.1586/erc.12.92.
Statins are a standard of care in many clinical settings such as acute myocardial infarction and for patients having or at risk of cardiovascular (CV) disease. This is based on a plethora of data showing reductions in CV events and mortality. The CV benefit of statins can be partly explained by their ability to inhibit of HMG-CoA reductase, which subsequently lowers cholesterol and decreases the formation of mevalonate. However, the inhibition of the mevalonate pathway decreases the formation of coenzyme Q10 (CoQ10) within the body. It has been a long-standing theory that statin-associated muscle pain (myalgia) is caused, or at least partly contributed by, a reduction in CoQ10 levels in muscle mitochondria. One of the main side effects of statins is myalgia, which causes the patient to either stop their statin or significantly reduce the dose of their statin. The question of whether CoQ10 can help treat statin myopathy is a common one encountered by clinicians in current day practice.
他汀类药物是许多临床情况下的标准治疗药物，如急性心肌梗死以及患有心血管（CV）疾病或有心血管疾病风险的患者。这是基于大量数据显示其可降低心血管事件和死亡率。他汀类药物的心血管益处部分可归因于其抑制HMG-CoA还原酶的能力，这随后会降低胆固醇并减少甲羟戊酸的形成。然而，甲羟戊酸途径的抑制会减少体内辅酶Q10（CoQ10）的形成。长期以来的理论认为，他汀类药物相关的肌肉疼痛（肌痛）是由肌肉线粒体中CoQ10水平降低引起的，或者至少部分是由其导致的。他汀类药物的主要副作用之一是肌痛，这会导致患者停止服用他汀类药物或大幅减少他汀类药物的剂量。CoQ10是否有助于治疗他汀类药物引起的肌病是当今临床医生在实践中经常遇到的问题。
