Idaho State University, Nuclear Engineering and Health Physics, P.O. Box 8106, Pocatello ID 83209, USA.
Health Phys. 2013 Jan;104(1):57-62. doi: 10.1097/HP.0b013e31826e17be.
The percentage of Am deposited in different parts of leg bones relative to the total leg activity was calculated from radiochemical analysis results from six whole body donors participating in the U.S. Transuranium and Uranium Registries (USTUR). In five of these six USTUR cases, the percentage of Am deposited in the knee region as well as in the entire leg was separately calculated relative to total skeletal activity. The purpose of this study is to find a region in the leg that is both suitable for in vivo measurement of Am deposited in the bones and has a good correlation with the total skeletal Am burden. In all analyzed cases, the femur was the bone with the highest percentage of Am deposited in the leg (48.8%). In the five cases that have complete whole skeletal analysis, the percentage of Am activity in the knee relative to entire skeletal activity was 4.8%, and the average value of its coefficient of variation was 10.6%. The percentage of Am in the leg relative to total skeletal activity was 20% with an average coefficient of variation of 13.63%. The Am activity in the knee as well as in the leg was strongly correlated (R = 99.5% and R = 99.1%, respectively) with the amount of Am activity in the entire skeleton using a simple linear relationship. The highest correlation was found between the amount of Am deposited in the knee and the amount of Am deposited in the entire skeleton. This correlation is important because it might enable an accurate assessment of the total skeletal Am burden to be performed from in vivo monitoring of the knee region. In all analyzed cases, an excellent correlation (R = 99.9%) was found between the amount of Am activity in the knee and the amount of Am activity in the entire leg. The results of this study suggest three simple models: two models to predict the total skeletal activity based on either leg or knee activity, and the third model to predict the total leg activity based on knee activity. The results also suggest that the knee region is a suitable position for in vivo measurements of Am deposited in the bones and also for an accurate and efficient detection system. Detector efficiency should be apparently calibrated based on only the Am burden in the knee region bones instead of Am activity deposited in the entire leg.
从参与美国超铀和铀登记处（USTUR）的六位全身供体的放射化学分析结果中，计算了腿部不同部位相对于总腿部活动的 Am 沉积百分比。在这六个 USTUR 病例中的五个中，分别计算了膝关节区域和整个腿部相对于总骨骼活动的 Am 沉积百分比。本研究的目的是找到腿部中适合测量骨骼中沉积的 Am 的区域，并且与总骨骼 Am 负荷具有良好的相关性。在所有分析的病例中，股骨是腿部中沉积的 Am 百分比最高的骨骼（48.8%）。在具有完整全身骨骼分析的五个病例中，膝关节中 Am 活性相对于整个骨骼活性的百分比为 4.8%，其变异系数的平均值为 10.6%。腿部中 Am 相对于总骨骼活性的百分比为 20%，平均变异系数为 13.63%。膝关节和腿部中的 Am 活性与整个骨骼中的 Am 活性具有很强的相关性（R = 99.5%和 R = 99.1%，分别），使用简单的线性关系。在膝关节和整个骨骼中沉积的 Am 量之间发现了最高的相关性。这种相关性很重要，因为它可能使能够从膝关节区域的体内监测准确评估总骨骼 Am 负荷。在所有分析的病例中，在膝关节和整个腿部中沉积的 Am 活性之间发现了极好的相关性（R = 99.9%）。本研究的结果提出了三个简单的模型：两个基于腿部或膝关节活动来预测总骨骼活动的模型，以及第三个基于膝关节活动来预测总腿部活动的模型。结果还表明，膝关节区域是骨骼中沉积的 Am 的体内测量的合适位置，也是准确和高效的检测系统。探测器效率显然应该仅根据膝关节区域骨骼中的 Am 负担而不是沉积在整个腿部中的 Am 活性进行校准。
