Rastogi R B, Singhal R L
Br J Pharmacol. 1978 Jan;62(1):131-6. doi: 10.1111/j.1476-5381.1978.tb07015.x.
1 Bilateral adrenalectomy suppressed body growth and increased the activity of tyrosine hydroxylase in rat striatum in a time-dependent manner. Fifteen days after adrenalectomy, the concentrations of noradrenaline were decreased significantly in hypothalamus and striatum, as were those of dopamine in brain stem and striatum. 2 Catechol-O-methyltransferase failed to change in response to adrenalectomy, but the activity of monoamine oxidase in cortex was significantly increased 7 days after surgery. These changes in various neurochemical parameters were even more pronounced 15 days after adrenal ablation. 3 Administration of corticosterone (10 mg/kg i.p.) to adrenalectomized rats effectively reversed the observed effects on brain amine metabolism. Corticosterone treatment for 7 days beginning from the 8th day of adrenalectomy virtually restored the concentrations of noradrenaline and dopamine as well as the activities of striatal tyrosine hydroxylase and cerebrocortical monoamine oxidase to the values seen for sham-operated controls. 4 Our data suggest that changes seen in brain noradrenaline and dopamine of adrenalectomized rats are specific to adrenocortical steroids and that these hormones play a role in the regulation of catecholamine formation.
1 双侧肾上腺切除术抑制大鼠身体生长，并以时间依赖性方式增加大鼠纹状体中酪氨酸羟化酶的活性。肾上腺切除术后15天，下丘脑和纹状体中去甲肾上腺素的浓度显著降低，脑干和纹状体中多巴胺的浓度也显著降低。2 儿茶酚-O-甲基转移酶对肾上腺切除术无反应，但术后7天皮质中单胺氧化酶的活性显著增加。肾上腺切除术后15天，各种神经化学参数的这些变化更为明显。3 给肾上腺切除的大鼠腹腔注射皮质酮（10mg/kg）可有效逆转观察到的对脑胺代谢的影响。从肾上腺切除术后第8天开始连续7天给予皮质酮治疗，几乎可将去甲肾上腺素和多巴胺的浓度以及纹状体酪氨酸羟化酶和脑皮质单胺氧化酶的活性恢复到假手术对照组的水平。4 我们的数据表明，肾上腺切除大鼠脑中去甲肾上腺素和多巴胺的变化是肾上腺皮质类固醇特有的，并且这些激素在儿茶酚胺形成的调节中起作用。
