长期给予血管加压素对大鼠脑和肾中儿茶酚胺水平及代谢的影响。
The effect of prolonged vasopressin administration on the level and metabolism of catecholamines in the rat brain and kidneys.
作者信息
Szmigielska H
出版信息
Acta Physiol Pol. 1976 May-Jun;27(3):259-64.
Dopamine (DA) and noradrenaline (NA) levels and activities of the enzymes metabolizing catecholamines were determined in the rat brain and kidneys during prolonged (4 weeks) administration of lysine vasopressin (LVP) and 2 weeks after its withdrawal. DA level was elevated during the whole period of experiment. NA level increased mainly after LVP withdrawal. Dopa-decarboxylase activity was elevated in all the experimental animals. Tyrosine and dopamine-beta-hydroxylase activities increased at the final period of LVP administration and after its withdrawal. Activities of MAO and COMT were markedly increased only after 3 weeks of LVP administration.
在长期（4周）给予赖氨酸加压素（LVP）期间以及停药2周后，测定大鼠脑和肾脏中多巴胺（DA）、去甲肾上腺素（NA）水平以及儿茶酚胺代谢酶的活性。在整个实验期间，DA水平升高。NA水平主要在LVP停药后升高。所有实验动物的多巴脱羧酶活性均升高。酪氨酸和多巴胺-β-羟化酶活性在LVP给药末期及停药后升高。仅在LVP给药3周后，单胺氧化酶（MAO）和儿茶酚-O-甲基转移酶（COMT）的活性才显著升高。
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