Reedy J E, Ruzevich S A, Noedel N R, Vitale L J, Merkle E J
Department of Surgery, St. Louis University Medical Center, MO 63110-0250.
J Heart Transplant. 1990 Mar-Apr;9(2):97-105.
Since 1986, 10 men and one woman were ambulatory while supported with mechanical assist devices as a bridge to heart transplantation. Four patients received a subclavian intraaortic balloon pump, two were supported with a Novacor left ventricular assist system, three patients received Pierce-Donachy ventricular assist devices, and one patient received a Jarvik 7 total artificial heart. One patient with an intraaortic balloon pump later received a left ventricular assist system because of hemodynamic deterioration despite the intraaortic balloon pump. Before device insertion all 11 patients were in cardiogenic shock despite inotropic and vasodilator support. The time of support ranged from 8 to 440 days (median, 24 days). In-house coverage by the circulatory support team was necessary only during the first 24 to 72 hours of support. When the patient's condition was stabilized, nursing staff monitored the devices with "on-call" availability of the circulatory support team. After implant of the device, all patients were able to perform activities of daily living. Once patients were able to walk in their hospital rooms, ambulation began in the hallways; frequency and distance were gradually increased. Four of the patients walked outside the hospital while tethered to the drive console. Daily physical therapy contributed to increased exercise tolerance. Protective isolation was used before and after transplantation to minimize the risk of infection. Sterile dressing changes (gown, gloves, mask) were applied to drive lines, cannula sites, and incisions. All invasive lines and catheters were removed as soon as the patient's clinical condition warranted, and noninvasive monitoring was used to decrease the chance of infection.(ABSTRACT TRUNCATED AT 250 WORDS)
自1986年以来,10名男性和1名女性在机械辅助装置的支持下能够走动,以此作为心脏移植的过渡手段。4名患者接受了锁骨下主动脉内球囊反搏,2名患者由诺瓦科尔左心室辅助系统支持,3名患者接受了皮尔斯 - 多纳希心室辅助装置,1名患者接受了贾维克7型全人工心脏。1名使用主动脉内球囊反搏的患者后来因尽管有主动脉内球囊反搏但血流动力学仍恶化而接受了左心室辅助系统。在植入装置前,所有11名患者尽管接受了强心剂和血管扩张剂支持仍处于心源性休克状态。支持时间为8至440天(中位数为24天)。仅在支持的最初24至72小时需要循环支持团队在医院内随时待命。当患者病情稳定后,护理人员监测装置,循环支持团队随时待命。装置植入后,所有患者都能够进行日常生活活动。一旦患者能够在病房内行走,便开始在走廊行走;频率和距离逐渐增加。4名患者在与驱动控制台相连的情况下走到医院外。每日的物理治疗有助于提高运动耐量。移植前后采用保护性隔离以尽量减少感染风险。对驱动线、插管部位和切口进行无菌换药(穿手术衣、戴手套、戴口罩)。一旦患者的临床状况允许,所有侵入性线路和导管都立即拔除,并采用非侵入性监测以减少感染机会。(摘要截选至250字)