School of Veterinary Sciences, University of Bristol, Bristol, UK.
J Vet Intern Med. 2013 Jan-Feb;27(1):99-105. doi: 10.1111/jvim.12011. Epub 2012 Nov 29.
Loss of urinary control after spinal cord injury increases risk of urinary tract disease and is problematical for owners of affected dogs.
To design, implant, and test a sacral nerve stimulating device for controlling urine voiding in paraplegic dogs.
Nine pet dogs with severe thoracolumbar spinal cord injury causing paraplegia, loss of hindquarter sensation, and incontinence for more than 3 months. The procedure was offered prospectively to owners of suitable candidates after the irreversibility of the incontinence had been ascertained.
Open label clinical study. Surgically implantable electrode "books" were designed for insertion and retention of mixed sacral nerves. Sacral nerves were accessed via laminectomy and stimulated to test their ability to elicit detrusor contraction and then inserted into the electrode book, which was attached to a subcutaneously implanted, externally activated receiver.
In 8/9 dogs, S2 nerves elicited the largest increases in intravesicular pressure with minimum stimulation and were placed in electrode books. Voiding efficiency was >90% in 8 of the 9 implanted dogs. No important detrimental effects of the procedure were observed.
This sacral nerve stimulating implant is a simple and apparently effective neuroprosthetic device that restores urine voiding in paraplegic dogs.
脊髓损伤后失去对尿液的控制会增加泌尿道疾病的风险，并且对受影响犬的主人来说也是个问题。
设计、植入并测试一种用于控制截瘫犬排尿的骶神经刺激装置。
9 只患有严重胸腰椎脊髓损伤导致截瘫、后躯感觉丧失和失禁超过 3 个月的宠物犬。在确定失禁不可逆转后，向合适候选犬的主人提供该程序的前瞻性选择。
开放性临床研究。设计了可植入的电极“书”，用于插入和保留混合骶神经。通过椎板切除术进入骶神经并进行刺激以测试其引发逼尿肌收缩的能力，然后将其插入电极书中，该电极书与皮下植入的外部激活接收器相连。
在 8/9 只犬中，S2 神经在最小刺激下引起最大的膀胱内压升高，并被放置在电极书中。在植入的 9 只犬中，有 8 只的排尿效率>90%。未观察到该手术有重要的不利影响。
这种骶神经刺激植入物是一种简单且显然有效的神经假体装置，可恢复截瘫犬的排尿功能。
