Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Israel.
DNA Cell Biol. 2013 Jan;32(1):2-7. doi: 10.1089/dna.2012.1889. Epub 2012 Nov 29.
Recent studies are delineating a detailed picture of the architecture and function of the endoplasmic reticulum (ER) and the early secretory pathway, showing the existence of dynamic compartmentalization of ER quality control and ER-associated degradation (ERAD) factors. The compartmentalization is regulated by ER protein load and in turn regulates protein processing and cell fate. This compartmentalization is intimately linked to the protein quality control processes, protein disposal through ERAD, the unfolded protein response, and the initiation of apoptosis. It includes novel compartments, the ER-derived quality control compartment (ERQC), vesicles implicated in "ERAD-tuning," and the mitochondria-associated membranes (MAMs).
最近的研究描绘了内质网 (ER) 和早期分泌途径的结构和功能的详细图片，显示了 ER 质量控制和 ER 相关降解 (ERAD) 因子的动态区室化的存在。这种区室化受 ER 蛋白负载的调节，反过来又调节蛋白质加工和细胞命运。这种区室化与蛋白质质量控制过程、通过 ERAD 进行的蛋白质处置、未折叠蛋白反应以及凋亡的启动密切相关。它包括新的区室，内质网衍生的质量控制区室 (ERQC)、涉及“ERAD 调谐”的小泡以及与线粒体相关的膜 (MAMs)。
