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Kami-untan-to (KUT) 可改善老龄大鼠的胆碱能缺陷。

Kami-untan-to (KUT) improves cholinergic deficits in aged rats.

机构信息

Oriental Medicine Research Center of the Kitasato institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108, Japan.

出版信息

Phytomedicine. 1996 Jan;2(3):253-8. doi: 10.1016/S0944-7113(96)80051-1.

Abstract

The Effects of the kampo (Japanese herbal) medicine, kami-untan-to (KUT)' on the central cholinergic system and passive avoidance behavior in aged rats (2 years old) were examined. When KUT was orally administered to aged rats, mean latency was significantly increased on passive avoidance test of step through type and choline acetyltransferase (ChAT) activity was increased in the frontoparietal cortex. Oral administration of KUT also increased ChAT mRNA levels in the basal forebrain and nerve growth factor (NGF) mRNA levels in the frontoparietal cortex as demonstrated by the reverse transcription-polymerase chain reaction (RT-PCR) method. These results suggest that oral administration of KUT improves age-related disturbance of memory via increasing effects of ChAT and NGF. KUT may be useful as a potential therapeutic agent in diseases caused by cholinergic deficit such as senile dementia of the Alzheimer type.

摘要

我们考察了汉方药(日本草药)葛根汤对老龄大鼠(2 岁)中枢胆碱能系统和被动回避行为的影响。当葛根汤被口服给予老龄大鼠时,其在穿梭型被动回避测试中的平均潜伏期显著增加,并且在前顶叶皮层中胆碱乙酰转移酶(ChAT)活性增加。正如逆转录-聚合酶链反应(RT-PCR)方法所证明的那样,葛根汤的口服给药还增加了基底前脑的 ChAT mRNA 水平和前顶叶皮层的神经生长因子(NGF)mRNA 水平。这些结果表明,葛根汤通过增加 ChAT 和 NGF 的作用改善了与年龄相关的记忆障碍。葛根汤可能作为一种有潜力的治疗剂用于治疗与胆碱能缺乏相关的疾病,如阿尔茨海默病型老年痴呆。

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