Centre for Complementary Health Studies and Postgraduate Medical School, University of Exeter, 25 Victoria Park Road, Exeter (UK) EX 2 4 NT.
Phytomedicine. 1995 Jul;2(1):67-71. doi: 10.1016/S0944-7113(11)80051-6.
The aim of this review was to assess controlled clinical trials of Hypericum as a treatment for depression. A systematic, combined computer and hand search revealed fourteen studies conducted against placebo and four against standard medication. Eight of the former and three of the latter met the predetermined methodological inclusion criteria and were admitted for analysis. The cumulative data shows that Hypericum is superior to placebo in alleviating symptoms of depression as quantified by the Hamilton Scale. It also seems equally effective as standard medication; the frequency of adverse drug reactions shows a clear advantage of the herbal over synthetic antidepressants. It is concluded that Hypericum is a safe and effective symptomatic treatment for various forms of depressions.
本综述旨在评估贯叶金丝桃作为抑郁症治疗方法的对照临床试验。通过系统的计算机和手工联合检索，共发现了 14 项针对安慰剂的研究和 4 项针对标准药物的研究。其中，前者中有 8 项，后者中有 3 项符合预定的方法学纳入标准，并被纳入分析。累积数据表明，贯叶金丝桃在缓解汉密尔顿量表量化的抑郁症状方面优于安慰剂。它似乎与标准药物同样有效；药物不良反应的频率显示出草药抗抑郁药明显优于合成抗抑郁药。结论是，贯叶金丝桃是一种安全有效的各种形式抑郁症的对症治疗方法。
