Dolphin Annette C
Department of Neuroscience, Physiology and Pharmacology, University College London, UK.
Biochim Biophys Acta. 2013 Jul;1828(7):1541-9. doi: 10.1016/j.bbamem.2012.11.019. Epub 2012 Nov 27.
Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together, except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α2δ subunits of these channels. These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels.
电压门控钙通道由主要的孔形成α1亚基组成，除T型通道外，还与β、α2δ亚基以及有时的γ亚基共同组成，这些亚基统称为辅助或附属亚基。本综述将聚焦于这些通道α2δ亚基的特性和作用。这些蛋白质主要位于细胞外，是与膜相关的蛋白质，它们会影响通道的运输、定位和生物物理特性。本文是名为《钙通道》的特刊的一部分。
