Moteki Masashi, Murano Takeyoshi, Kurosu Takumi, Kataoka Manabu, Nakano Mizuaki, Hiruta Nobuyuki, Shirai Kohji
Department of Clinical Laboratory, Toho University Sakura Medical Center, Sakura 285-8741, Japan.
Rinsho Byori. 2012 Aug;60(8):734-9.
Many risk factors for coronary arterial diseases have been reported. Lipoprotein lipase (LPL) mass in serum has been suggested to be a new risk factor, but remains to be proven. The cardio-ankle vascular index (CAVI) was developed as a new arterial stiffness index and is considered to be a surrogate marker of arteriosclerosis. The purpose of this study was to establish the role of LPL mass in arteriosclerosis by examining the relationship between LPL mass and CAVI in patients with arteriosclerotic risk factors. We studied 216 patients who attended our diabetic center with diagnoses of diabetes, hypertension and/or dyslipidemia. CAVI was measured using VaSera1500 (Fukuda Denshi, Tokyo). Serum level of LPL mass was measured by ELISA(Sekisui Co. Ltd.). When the subjects were divided by a CAVI cutoff level of 9.0, the glucose level, glycohemoglobin A1c (HbA1c) level and systolic blood pressure level were significantly higher in the over 9.0 individuals than in the under 9.0 individuals (p < 0.05). CAVI level was significantly higher in patients with hyperglycemia and hypertension. LPL mass was lower in subjects with higher CAVI than in those with lower CAVI. CAVI level correlated inversely with LPL mass. CAVI adjusted for the age was associated significantly with LPL mass. These results suggest that decreased LPL mass may be a risk marker for arteriosclerosis as indicated by the surrogate marker CAVI.
许多冠状动脉疾病的风险因素已被报道。血清中的脂蛋白脂肪酶（LPL）质量被认为是一种新的风险因素，但仍有待证实。心踝血管指数（CAVI）作为一种新的动脉僵硬度指数而被开发出来，被认为是动脉硬化的替代标志物。本研究的目的是通过研究有动脉硬化风险因素的患者中LPL质量与CAVI之间的关系，来确定LPL质量在动脉硬化中的作用。我们研究了216名到我们糖尿病中心就诊，被诊断患有糖尿病、高血压和/或血脂异常的患者。使用VaSera1500（福田电子，东京）测量CAVI。通过ELISA（积水株式会社）测量血清LPL质量水平。当受试者以CAVI临界值9.0进行划分时，CAVI大于9.0的个体的血糖水平、糖化血红蛋白A1c（HbA1c）水平和收缩压水平显著高于CAVI小于9.0的个体（p<0.05）。高血糖和高血压患者的CAVI水平显著更高。CAVI较高的受试者的LPL质量低于CAVI较低的受试者。CAVI水平与LPL质量呈负相关。校正年龄后的CAVI与LPL质量显著相关。这些结果表明，LPL质量降低可能是由替代标志物CAVI所表明的动脉硬化的风险标志物。
