Institutes of Brain Science and State Key Laboratory for Medical Neurobiology, Fudan University, Shanghai, China.
Auton Neurosci. 2013 Jan;173(1-2):39-44. doi: 10.1016/j.autneu.2012.11.003. Epub 2012 Nov 27.
Bilateral internal carotid artery ligation (BICL) rat model is one of the chronic cerebral hypoperfusion animal models used for investigating brain dysfunction related diseases. Cerebral blood flow decreases in different cerebral regions in a time-dependent manner after the BICL. However little is known about the cerebral vasculature change in the brain after the BICL. In the current study, the bilateral internal carotid arteries of the juvenile rats were permanently ligated and the change of the cerebral vasculature was studied 7, 14 and 21 days after the BICL. In the juvenile rats, 7 days after the BICL, the functional vascular area was decreased significantly in the anterior half of the cerebral cortex, but it had only little decrease in the posterior half of the cerebral cortex and hippocampus. However, at the time points of 14 and 21 days after the surgery, the functional vascular area throughout the whole cerebral cortex and hippocampus was almost similar to those in the sham control rats. In conclusion, the results from our current study showed that in the BICL hypoperfusion model in young rats, the brain functional vascular area was impaired initially in certain brain regions after the artery ligation, but likely to be quickly self-recovered late after. The results suggest that the brain vasculature in young rats has plasticity to external insult caused by cerebral hypoperfusion.
双侧颈内动脉结扎（BICL）大鼠模型是用于研究与脑功能障碍相关疾病的慢性脑低灌注动物模型之一。BICL 后，不同脑区的脑血流呈时间依赖性下降。然而，关于 BICL 后大脑血管的变化知之甚少。在本研究中，永久性结扎幼鼠双侧颈内动脉，研究 BICL 后 7、14 和 21 天大脑血管的变化。在幼鼠中，BICL 后 7 天，大脑皮质前半部分的功能性血管面积显著减少，但后半部分和海马区的减少幅度较小。然而，在手术后 14 和 21 天，整个大脑皮质和海马区的功能性血管面积几乎与假手术对照组相似。总之，本研究结果表明，在年轻大鼠的 BICL 低灌注模型中，动脉结扎后某些脑区的脑功能血管面积最初受损，但可能在后期迅速自我恢复。结果提示年轻大鼠的脑血管对外源性脑低灌注损伤具有可塑性。
