Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, PR China.
Respir Med. 2013 Feb;107(2):161-71. doi: 10.1016/j.rmed.2012.11.001. Epub 2012 Nov 27.
Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of eosinophilic airway inflammation. Our aim was to study associations between FeNO in Chinese children in two cities and asthma, asthmatic symptoms, rhinitis, eczema, and selected childhood and home environmental factors. A random sample of children in Shanghai (n = 187) and Taiyuan (n = 127), and additional randomly selected children reporting current wheeze (n = 115) were invited for FeNO measurements by NIOX MINO. A questionnaire survey was performed among all subjects (12-14 y) in 59 classes in Shanghai and 44 in Taiyuan. Associations were studied using multiple linear regression using 10log transformed FeNO data and mutual adjustment. The geometric mean FeNO in the random sample (GM ± GSD) was higher in Shanghai (16.2 ± 1.9 ppb) as compared to Taiyuan (12.8 ± 1.6 ppb) (P < 0.001). In the total material (n = 429), Shanghai residency (P = 0.001), male gender (P = 0.02), parental asthma/allergy (P = 0.04), doctors' diagnosed asthma (DDA) (P < 0.001) and current wheeze (P < 0.001) were associated with higher FeNO levels. In non-wheezers (n = 291), Shanghai residency (P = 0.007), male gender (P = 0.002), DDA (P = 0.04), current rhinitis (P = 0.004) and reported pollen/furry pet allergy (P = 0.04) were positively associated with FeNO. In wheezers (n = 138), DDA was the only significant factor (P = 0.009). In conclusion, male gender, current wheeze, DDA, parental asthma/allergy, current rhinitis, pollen/furry pet allergy can be independent determinants of increased FeNO. The lower level of FeNO in Taiyuan is in agreement with previous studies showing lower prevalence of asthma and allergy in Taiyuan as compared to Shanghai.
呼出气一氧化氮分数（FeNO）是一种非侵入性的气道嗜酸性粒细胞炎症生物标志物。我们的目的是研究中国两个城市儿童的 FeNO 与哮喘、哮喘症状、鼻炎、湿疹以及一些儿童期和家庭环境因素之间的关系。我们邀请了上海（n=187）和太原（n=127）的随机儿童样本以及报告当前喘息的额外随机选择的儿童（n=115）进行 NIOX MINO 的 FeNO 测量。在上海的 59 个班级和太原的 44 个班级中对所有（12-14 岁）受试者进行问卷调查。使用 10log 转换后的 FeNO 数据进行多元线性回归分析，并进行相互调整。随机样本的几何均数 FeNO（GM±GSD）在上海（16.2±1.9 ppb）高于太原（12.8±1.6 ppb）（P<0.001）。在总样本（n=429）中，上海居住（P=0.001）、男性（P=0.02）、父母哮喘/过敏（P=0.04）、医生诊断的哮喘（DDA）（P<0.001）和当前喘息（P<0.001）与更高的 FeNO 水平相关。在非喘息者（n=291）中，上海居住（P=0.007）、男性（P=0.002）、DDA（P=0.04）、当前鼻炎（P=0.004）和报告花粉/毛绒宠物过敏（P=0.04）与 FeNO 呈正相关。在喘息者（n=138）中，DDA 是唯一显著的因素（P=0.009）。总之，男性、当前喘息、DDA、父母哮喘/过敏、当前鼻炎、花粉/毛绒宠物过敏可能是 FeNO 升高的独立决定因素。太原较低的 FeNO 水平与先前的研究一致，表明与上海相比，太原的哮喘和过敏患病率较低。
