Institute of Medical Sciences, Medical College, Rzeszów University, Warzywna 1a, 35-310 Rzeszów, Poland.
Department of Allergology and Cystic Fibrosis, State Hospital 2 in Rzeszów, Lwowska 60, 35-301 Rzeszów, Poland.
Adv Respir Med. 2022 Jul 20;90(4):237-245. doi: 10.3390/arm90040033.
Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of eosinophilic airway inflammation and therapeutic response to corticosteroid treatment of respiratory diseases. Atopic dermatitis (AD), one of the most common allergic conditions of the skin, is a factor influencing the increase of FeNO. The main aim of this study was to determine differences between levels of FeNO in patients with AD and healthy controls as measured by an electrochemical analyzer. In total, 54 teenagers and adults with AD were recruited and compared with 34 healthy volunteers. The measurements of FeNO were taken using the Hyp’Air FeNO in participants. FeNO was statistically significantly higher in patients with AD than in healthy controls (60.5 ± 35.1 vs. 14.8 ± 5.1 ppb, p < 0.001). We found a strong positive significant correlation between FeNO and the number of positive skin prick tests among AD patients (R = 0.754, p < 0.001). There was no correlation between FeNO and duration of disease as well as SCORAD index among patients. Moreover, we also found no FeNO difference between the mild and moderate forms of AD. The presence of AD and the increasing number of positive skin prick tests increase FeNO, so the results of this measurement should be interpreted with caution in patients with respiratory diseases suffering from AD.
呼出气一氧化氮（FeNO）分数是气道嗜酸性粒细胞炎症的非侵入性生物标志物，也是皮质类固醇治疗呼吸系统疾病疗效的预测指标。特应性皮炎（AD）是最常见的皮肤过敏疾病之一，是影响 FeNO 增加的因素之一。本研究的主要目的是通过电化学分析仪确定 AD 患者和健康对照组之间 FeNO 水平的差异。共招募了 54 名青少年和成年 AD 患者，并与 34 名健康志愿者进行了比较。在参与者中使用 Hyp’Air FeNO 测量 FeNO。AD 患者的 FeNO 水平明显高于健康对照组（60.5 ± 35.1 比 14.8 ± 5.1 ppb，p < 0.001）。我们发现 AD 患者的 FeNO 与阳性皮肤点刺试验数量之间存在显著正相关（R = 0.754，p < 0.001）。AD 患者的 FeNO 与疾病持续时间和 SCORAD 指数之间无相关性。此外，我们还发现 AD 患者的轻度和中度形式之间的 FeNO 无差异。AD 的存在和阳性皮肤点刺试验数量的增加会增加 FeNO，因此患有 AD 的呼吸系统疾病患者的该测量结果应谨慎解释。
