UCL Institute of Liver and Digestive Health, University College London, UK.
Photodiagnosis Photodyn Ther. 2012 Dec;9(4):287-92. doi: 10.1016/j.pdpdt.2012.03.005. Epub 2012 Aug 30.
In patients with unresectable cholangiocarcinoma, photodynamic therapy (PDT) with porfimer sodium promotes biliary drainage and may improve survival and quality of life.
To prospectively evaluate the safety and efficacy of PDT in patients with locally advanced biliary tract carcinoma.
Eligible patients had unresectable, histologically confirmed disease, a Karnofsky performance status of ≥30% and life expectancy >12 weeks. Patients received 2mg/kg i.v. of porfimer sodium, followed by endobiliary laser activation and stent replacement 48 h later. Patients were assessed clinically and radiologically before treatment and on day 28, and followed up thereafter at three-monthly intervals until death.
36 patients were entered over an 18 months period: 14 males, 22 females, with a median age of 65 (30-79)yr and performance status of 80 (50-100). PDT was technically successful in all cases and was generally well tolerated; there was no grade 4 toxicity and no treatment-associated mortality. The median survival was 12 (1-84) months.
Porfimer sodium PDT can be delivered safely to patients with biliary tract cancer and is suitable for testing in phase III studies (UKCRN ID 1218).
在无法切除的胆管癌患者中，钅卟啉单甲醚光动力疗法（PDT）可促进胆汁引流，并可能改善生存和生活质量。
前瞻性评估钅卟啉单甲醚 PDT 治疗局部晚期胆道癌患者的安全性和疗效。
符合条件的患者患有不可切除的、组织学证实的疾病，卡氏行为状态评分≥30%，预期寿命>12 周。患者接受 2mg/kg 的静脉注射钅卟啉单甲醚，48 小时后进行经内镜胆管内激光激活和支架置换。在治疗前、第 28 天和此后每三个月进行临床和影像学评估，直至死亡。
在 18 个月的时间内，共纳入 36 例患者：14 例男性，22 例女性，中位年龄为 65（30-79）岁，行为状态评分为 80（50-100）。所有病例 PDT 技术均成功，且耐受性良好；无 4 级毒性，无治疗相关死亡。中位生存期为 12（1-84）个月。
钅卟啉单甲醚 PDT 可安全地用于胆管癌患者，适合在 III 期研究中进行测试（英国癌症研究 UKCRN 注册号 1218）。
