Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Front Neuroendocrinol. 2013 Apr;34(2):88-94. doi: 10.1016/j.yfrne.2012.11.001. Epub 2012 Nov 27.
G protein-coupled receptors (GPCRs) are the largest class of integral membrane protein receptors in the human genome. We examined here the reports whether the GnRH receptor (GnRHR) interacts with a single or multiple types of G proteins. It seems that the GnRHR, as other GPCRs, alternates between various conformations and is stabilized by its ligands, other modulators and intracellular partners in selective conformations culminating in coupling with a single type or multiple G proteins in a cell- and context-specific manner.
G 蛋白偶联受体 (GPCRs) 是人类基因组中最大的一类整合膜蛋白受体。我们在此研究了 GnRH 受体 (GnRHR) 是否与单一或多种类型的 G 蛋白相互作用。似乎 GnRHR 与其他 GPCR 一样，在各种构象之间交替，并通过其配体、其他调节剂和细胞内伴侣在选择性构象中稳定，最终以细胞和上下文特异性的方式与单一类型或多种 G 蛋白偶联。
