L'UNAM, Université de Nantes, Polytech Nantes, Institut des Matériaux Jean Rouxel, Rue Christian Pauc, BP 50609, 44306 Nantes Cedex 3, France.
Acta Biomater. 2013 Mar;9(3):5740-50. doi: 10.1016/j.actbio.2012.11.020. Epub 2012 Nov 28.
The influence of cellulose ether additives (CEAs) on the performance of final calcium phosphate cement (CPC) products is thoroughly investigated. Four CEAs were added into the liquid phase of apatitic CPCs based on the hydrolysis of α-tricalcium phosphate, to investigate the influence of both molecular weight and degree of substitution on the CPCs' properties, including handling (e.g. injectability, cohesion, washout resistance and setting time), microstructure (e.g. porosity and micromorphology) and mechanical properties (e.g. fracture toughness and compressive strength). The results showed that even a small amount of CEAs modified most of these CPCs' features, depending on the structural parameters of the CEAs. The CEAs dramatically improved the injectability, cohesion and washout resistance of the pastes, prolonged the final setting time and increased the porosity of CPCs. Moreover, the CEAs had an evident toughening effect on CPCs, and this effect become more significant with increasing molecular weight and mass fraction of CEAs, inducing a significant tolerance to damage. Overall, the molecular weight of CEAs played a major role compared to their degree of substitution in CPCs' performances.
深入研究了纤维素醚添加剂（CEAs）对最终磷酸钙水泥（CPC）性能的影响。将四种 CEAs 添加到基于α-磷酸三钙水解的磷灰石 CPC 的液相中，研究了分子量和取代度对 CPC 性能的影响，包括处理性能（如可注射性、内聚性、耐冲洗性和凝固时间）、微观结构（如孔隙率和微观形貌）和机械性能（如断裂韧性和抗压强度）。结果表明，即使少量的 CEAs 也能根据 CEAs 的结构参数来改变大多数 CPC 的特性。CEAs 显著提高了糊剂的可注射性、内聚性和耐冲洗性，延长了最终凝固时间，并增加了 CPC 的孔隙率。此外，CEAs 对 CPC 具有明显的增韧作用，并且随着 CEAs 的分子量和质量分数的增加，这种作用变得更加显著，从而对损伤具有明显的耐受性。总体而言，与取代度相比，CEAs 的分子量在 CPC 的性能中起着主要作用。
