失去抑制：将皮层 GABA 能中间神经元与精神分裂症联系起来。
Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia.
机构信息
Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.
出版信息
Neurobiol Dis. 2013 May;53:36-48. doi: 10.1016/j.nbd.2012.11.013. Epub 2012 Nov 29.
Abstract
GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of cortical function. The diverse types of cINs are classified into subgroups according to their morphology, intrinsic physiology, neurochemical markers and synaptic targeting. Recent advances in mouse genetics, imaging and electrophysiology techniques have greatly advanced our efforts to understand the role of normal cIN function and its dysfunction in neuropsychiatric disorders. In schizophrenia (SCZ), a wealth of data suggests that cIN function is perturbed, and that interneuron dysfunction may underlie key symptoms of the disease. In this review, we discuss the link between cINs and SCZ, focusing on the evidence for GABAergic signaling deficits from both SCZ patients and mouse models.
摘要
大脑皮层的 GABA 能中间神经元（cINs）在皮质功能的许多方面发挥着关键作用。根据形态、内在生理学、神经化学标记和突触靶向，cIN 可分为不同的亚型。近年来，在小鼠遗传学、成像和电生理学技术方面的进展，极大地推动了我们对正常 cIN 功能及其在神经精神疾病中的功能障碍的作用的理解。在精神分裂症（SCZ）中，大量数据表明 cIN 功能受到干扰，而中间神经元功能障碍可能是该疾病关键症状的基础。在这篇综述中，我们讨论了 cIN 与 SCZ 之间的联系，重点介绍了来自 SCZ 患者和小鼠模型的 GABA 能信号传递缺陷的证据。
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