Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Surg Obes Relat Dis. 2013 Jan-Feb;9(1):1-6. doi: 10.1016/j.soard.2012.07.021. Epub 2012 Sep 11.
Data regarding the management of bariatric patients with cirrhosis are scarce, and there is no strong evidence that supports a specific approach for this group of patients. The aim of this study was to review our experience with cirrhotic patients undergoing bariatric surgery.
A prospectively maintained database was reviewed to assess the outcomes of bariatric surgery for patients with known cirrhosis and for patients with cirrhosis discovered at surgery (unknown cirrhosis).
From April 2004 to September 2011, 23 patients (12 with known cirrhosis and 11 with unknown cirrhosis) met inclusion criteria. There were 14 females and 9 males with a mean age of 51.5 ± 8.3 and a mean body mass index of 48.2 ± 8.6 kg/m2. Child-Pugh classes were A (n = 22) and B (n = 1). Patients had a high frequency of diabetes (83%), dyslipidemia (61%), and hypertension (83%). Procedures performed were laparoscopic Roux-en-Y gastric bypass (LRYGB) (n = 14), laparoscopic sleeve gastrectomy (LSG) (n = 8), and laparoscopic adjustable gastric banding (n = 1). Two patients underwent LSG successfully after transjugular intrahepatic portosystemic shunt. Mean length of hospital stay was 4.3 ± 2.7 days. Complications developed in 8 patients. One patient died of unknown cause 9 months after surgery. No patients had liver decompensation after surgery. The patients lost 67.4% ± 30.9% of their excess weight at 12 months follow-up and 67.7% ± 24.8% at 37 months follow-up.
LRYGB and LSG can be performed without prohibitive complication rates in carefully selected patients with cirrhosis. In our experience, bariatric patients with cirrhosis achieved excellent weight loss and improvement in obesity-related co-morbidities.
有关肝硬化患者的管理数据很少,并且没有强有力的证据支持针对这组患者的特定方法。本研究的目的是回顾我们对接受减肥手术的肝硬化患者的经验。
回顾性维护数据库,以评估已知肝硬化患者和手术中发现肝硬化患者(未知肝硬化)的减肥手术结果。
从 2004 年 4 月至 2011 年 9 月,有 23 名患者(12 名已知肝硬化和 11 名未知肝硬化)符合纳入标准。有 14 名女性和 9 名男性,平均年龄为 51.5 ± 8.3 岁,平均体重指数为 48.2 ± 8.6 kg/m2。Child-Pugh 等级为 A(n = 22)和 B(n = 1)。患者有很高的糖尿病(83%),血脂异常(61%)和高血压(83%)的发病率。进行的手术包括腹腔镜 Roux-en-Y 胃旁路术(LRYGB)(n = 14),腹腔镜袖状胃切除术(LSG)(n = 8)和腹腔镜可调节胃束带术(n = 1)。两名患者在经颈内静脉肝内门体分流术后成功进行了 LSG。平均住院时间为 4.3 ± 2.7 天。有 8 名患者发生并发症。一名患者术后 9 个月死于不明原因。手术后没有患者出现肝功能失代偿。患者在 12 个月随访时丢失了其超重体重的 67.4% ± 30.9%,在 37 个月随访时丢失了 67.7% ± 24.8%。
在仔细选择的肝硬化患者中,LRYGB 和 LSG 可以安全地进行,而不会出现过高的并发症发生率。根据我们的经验,肝硬化肥胖症患者的体重减轻和肥胖相关合并症的改善效果非常好。