Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
J Microbiol Immunol Infect. 2015 Jun;48(3):335-9. doi: 10.1016/j.jmii.2012.09.004. Epub 2012 Nov 30.
An 89-year-old man suffered from and died of necrotizing pneumonia with rapid progression and cavity formation due to methicillin-resistant Staphylococcus aureus (MRSA). He was at no risk for hospital-acquired MRSA infection. His MRSA exhibited genotype ST5/spa2(t002)/agr2/SCCmecII/coagulaseII and was negative for Panton-Valentine leukocidin, indicating the New York/Japan clone (the predominant epidemic hospital-acquired MRSA clone in Japan). However, this strain expressed the cytolytic peptide (phenol-soluble modulin or δ-hemolysin) genes at high level, similar to USA300 (the most common community-acquired MRSA in the United States), indicating a variant of the New York/Japan clone with an important feature of community-acquired MRSA.
一位 89 岁男性因耐甲氧西林金黄色葡萄球菌（MRSA）引起的坏死性肺炎迅速进展并形成空洞而发病并死亡，他不存在医院获得性 MRSA 感染的风险。他的 MRSA 表现出 ST5/spa2(t002)/agr2/SCCmecII/coagulaseII 基因型，且对 Panton-Valentine 白细胞毒素呈阴性，表明为纽约/日本克隆株（日本主要流行的医院获得性 MRSA 克隆株）。然而，该菌株高水平表达细胞溶解肽（酚可溶性调节蛋白或 δ-溶血素）基因，类似于 USA300（美国最常见的社区获得性 MRSA），表明该菌株是具有社区获得性 MRSA 重要特征的纽约/日本克隆株的一个变体。
