Cancer Pharmacology Unit, ANZAC Research Institute, Concord Repatriation and General Hospital, Sydney, NSW 2139, Australia.
Trends Endocrinol Metab. 2013 Apr;24(4):174-83. doi: 10.1016/j.tem.2012.10.006. Epub 2012 Nov 29.
Cachexia has a devastating impact on survival and quality of life for many cancer patients. A better understanding of the underlying mechanisms leading to the complex metabolic defects of cachexia, coupled with effective treatment options, will improve management of wasting in cancer patients. The growing appreciation that cancer cachexia results from the spillover effects of cytokine production by tumors on the integrated regulation of energy balance in different organs identifies potential therapeutic options. However, targeting such tumorkines requires a comprehensive understanding of their normal as well as pathophysiological functions, especially the crosstalk between inflammatory signaling and metabolic dysregulation. Recent advances in characterizing the surprising parallels between obesity and cancer cachexia provide new insights into these apparently divergent syndromes.
恶病质对许多癌症患者的生存和生活质量都有着毁灭性的影响。更好地理解导致恶病质复杂代谢缺陷的潜在机制，并结合有效的治疗方案，将有助于改善癌症患者的消耗状况管理。人们越来越认识到，癌症恶病质是肿瘤细胞产生细胞因子对不同器官能量平衡的综合调节产生溢出效应的结果，这为治疗提供了潜在的选择。然而，针对这些肿瘤因子需要全面了解它们的正常和病理生理功能，特别是炎症信号和代谢失调之间的串扰。最近在描述肥胖症和癌症恶病质之间令人惊讶的相似之处方面的进展，为这些看似不同的综合征提供了新的见解。
