维甲酸在10T1/2细胞转化过程中的作用。
Action of retinoids during transformation of 10T1/2 cells.
作者信息
Przybyszewska M, Janik P, Miłoszewska J, Szaniawska B
机构信息
Department of Tumor Biology, M. Skłodowska-Curie Institute of Oncology, Warsaw, Poland.
出版信息
Neoplasma. 1990;37(1):37-41.
PMID:2320179
Abstract
The effect of three retinoids, 13-cis-retinoic acid, arotinoid ethyl sulfone and retinal acetate, on methylcholanthrene (MCA) induced transformation of 10T1/2 cells was studied. It appears that 13-cis-retinoic acid and arotinoid ethyl sulfone prevent transformation in a direct way at the last stage of carcinogenesis. Retinal acetate, however, requires cell-to-cell contacts to inhibit the transformation of 10T1/2 cells.
摘要
研究了三种类视黄醇，即13-顺式视黄酸、芳维甲酸乙酯砜和醋酸视黄醛，对甲基胆蒽（MCA）诱导的10T1/2细胞转化的影响。结果表明，13-顺式视黄酸和芳维甲酸乙酯砜在致癌作用的最后阶段以直接方式阻止转化。然而，醋酸视黄醛需要细胞间接触来抑制10T1/2细胞的转化。
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