Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Otol Neurotol. 2013 Jan;34(1):141-50. doi: 10.1097/MAO.0b013e318278bf38.
To provide an up-to-date review of treatment and outcomes of patients with squamous cell carcinoma (SCCA) involving the temporal bone.
Retrospective cohort study of all patients treated at our institution for SCCA of the temporal bone between 1995 and 2007 with follow-up until 2011. Factors evaluated were demographics, presenting findings, follow-up time, previous treatment, workup, stage, surgical intervention, adjuvant therapy, histopathologic findings, recurrence, and survival.
Tertiary care academic medical center.
Thirty patients with SCCA of the temporal bone, originating from the external auditory canal and adjacent sites.
Surgical resection ± adjuvant therapy. Lateral temporal bone resection was the primary and most aggressive procedure performed.
Disease-free survival.
The overall disease free survival for this series when considering both external auditory canal and adjacent site SCCAs was 70%. When evaluated by tumor stage, disease-free survival was as follows: T1 tumors = 100%, T2 tumors = 100%, T3 tumors = 67%, and T4 tumors = 56%. Aggressive tumors of this series originating at periauricular sites behaved in a similar manner to primary canal tumors. Need for surgical resection of CN VII was associated with diminished survival on multivariate analysis.
Lateral temporal bone resection provides comparable disease free survival rates to more radical surgical therapy. Such resection is appropriate for many SCCAs of the external auditory canal and adjacent sites, as these tumors are similar in disease progression and prognosis. CN VII involvement portends a poor outcome.
提供最新的治疗和结果回顾，涉及颞骨鳞状细胞癌（SCCA）的患者。
回顾性队列研究，在 1995 年至 2007 年期间在我们机构接受颞骨 SCCA 治疗的所有患者，并随访至 2011 年。评估的因素包括人口统计学、表现发现、随访时间、先前治疗、工作流程、分期、手术干预、辅助治疗、组织病理学发现、复发和生存。
三级保健学术医疗中心。
30 例颞骨 SCCA 患者，源自外耳道和相邻部位。
手术切除±辅助治疗。外侧颞骨切除术是主要和最激进的程序。
无病生存率。
考虑到外耳道和相邻部位 SCCA，本系列的总体无病生存率为 70%。根据肿瘤分期评估，无病生存率如下：T1 肿瘤=100%，T2 肿瘤=100%，T3 肿瘤=67%，T4 肿瘤=56%。本系列起源于耳周部位的侵袭性肿瘤的行为与原发性管肿瘤相似。多变量分析显示，CN VII 手术切除的需要与生存下降相关。
外侧颞骨切除术提供与更激进手术治疗相当的无病生存率。这种切除适用于许多外耳道和相邻部位的 SCCA，因为这些肿瘤在疾病进展和预后方面相似。CN VII 受累预示预后不良。
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