Pasqualetti P, Colantonio D, Casale R
Dipartimento di Medicina Interna, Università degli Studi di L'Aquila degli Abruzzi.
Minerva Med. 1990 Mar;81(3):129-33.
The relationship between initial percentage of bone marrow plasma cells and survival was studied in a group of 70 patients affected with multiple myeloma. All patients had a complete follow-up. The initial percentage of plasma cells shows a highly significant correlation with survival. Moreover, the percentage of bone marrow plasma cells is also correlated with the levels of hemoglobinemia and serum or urinary monoclonal component. The patients were divided in three groups according to the percentage of bone marrow plasma cells: group A: less than 20%; group B: 21-40%; group C: greater than 41%. The mean survival times of these three groups are significantly different, as well as their survival curves. The initial percentage of plasma cells in bone marrow is an useful parameter for estimating survival and predicting prognosis, and it can be an additional factor in the clinical staging of multiple myeloma, while the effectiveness of therapy can be monitored by sequential bone marrow aspirates.
在一组70例多发性骨髓瘤患者中，研究了骨髓浆细胞初始百分比与生存率之间的关系。所有患者均进行了完整的随访。浆细胞初始百分比与生存率呈现高度显著的相关性。此外，骨髓浆细胞百分比还与血红蛋白血症水平以及血清或尿单克隆成分相关。根据骨髓浆细胞百分比，将患者分为三组：A组：低于20%；B组：21%-40%；C组：高于41%。这三组的平均生存时间以及生存曲线均存在显著差异。骨髓中浆细胞的初始百分比是评估生存和预测预后的有用参数，并且它可以作为多发性骨髓瘤临床分期的一个附加因素，同时可通过连续的骨髓穿刺来监测治疗效果。
