Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.
Kidney Int. 2012 Dec;82(12):1248-50. doi: 10.1038/ki.2012.338.
Chronic kidney disease (CKD) is characterized by accelerated vascular calcification, which may in part be caused by deficiency of the anti-aging factor Klotho. Lau et al. demonstrate that administration of active vitamin D and its analog decreases aortic calcification in association with increases in two potent calcification inhibitors--the secreted form of Klotho and vascular osteopontin. These data might provide a new perspective on the association of active vitamin D with improved survival in patients with CKD.
慢性肾脏病（CKD）的特征是血管钙化加速，这在一定程度上可能是由于抗衰老因子 Klotho 的缺乏所致。Lau 等人证明，活性维生素 D 及其类似物的给药可降低主动脉钙化，同时增加两种有效的钙化抑制剂——Klotho 的分泌形式和血管骨桥蛋白。这些数据可能为活性维生素 D 与改善 CKD 患者生存的相关性提供一个新的视角。
Zotero 插件