Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
Am J Epidemiol. 2012 Dec 15;176(12):1169-76. doi: 10.1093/aje/kws235. Epub 2012 Dec 2.
The impact of low vitamin D status on asthma development is unclear. The authors investigated the relation between the baseline serum 25-hydroxyvitamin D (25(OH)D) level and incident asthma in adults, including possible effect modification by allergy status, using allergic rhinitis as a proxy measure. A cohort of 25,616 Norwegian adults aged 19-55 years participated in 2 surveys of the Nord-Trøndelag Health Study known as HUNT 2 (1995-1997) and HUNT 3 (2006-2008). Of this cohort, a nested case-control study included 584 new-onset asthma cases and 1,958 nonasthma controls whose baseline serum 25(OH)D levels were measured. After adjustment for potential asthma risk factors, the baseline serum level of 25(OH)D (<50 nmol/L) was not significantly associated with asthma in either women (adjusted odds ratio = 0.94, 95% confidence interval (CI): 0.67, 1.32) or men (adjusted odds ratio = 1.47, 95% CI: 0.93, 2.32). In men, allergic rhinitis modified the association with the adjusted odds ratio being 0.87 (95% CI: 0.36, 2.06) among men with allergic rhinitis and 2.32 (95% CI: 1.06, 5.10) among men without allergic rhinitis. The serum 25(OH)D level was not associated with incident asthma in women, regardless of allergy status. Low vitamin D status was not significantly associated with incident asthma in most adults, but it may have increased risk among men without allergy.
维生素 D 状态低下对哮喘发病的影响尚不清楚。作者研究了成年人基线血清 25-羟维生素 D（25(OH)D）水平与新发哮喘之间的关系，包括过敏状态的可能修饰作用，使用过敏性鼻炎作为替代指标。一个由 25616 名年龄在 19-55 岁的挪威成年人组成的队列参加了两次挪威特隆赫姆健康研究（HUNT）调查，分别称为 HUNT2（1995-1997 年）和 HUNT3（2006-2008 年）。在该队列中，一项巢式病例对照研究纳入了 584 例新发哮喘病例和 1958 例非哮喘对照者，其基线血清 25(OH)D 水平进行了测量。在调整了潜在的哮喘危险因素后，基线血清 25(OH)D 水平（<50 nmol/L）与女性（调整后的优势比=0.94，95%置信区间[CI]：0.67，1.32）或男性（调整后的优势比=1.47，95%CI：0.93，2.32）的哮喘均无显著相关性。在男性中，过敏性鼻炎修饰了这种关联，过敏性鼻炎男性的调整后的比值比为 0.87（95%CI：0.36，2.06），而无过敏性鼻炎的男性为 2.32（95%CI：1.06，5.10）。无论过敏状态如何，血清 25(OH)D 水平与女性新发哮喘均无相关性。在大多数成年人中，维生素 D 状态低下与新发哮喘无显著相关性，但在无过敏的男性中，这种相关性可能会增加。
