Kumor K M, Clark W C, Janal M N, Haertzen C A
National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
Pharmacol Biochem Behav. 1990 Feb;35(2):397-404. doi: 10.1016/0091-3057(90)90176-i.
Profiles of the subjective and physiologic effects of opioid drugs in man cannot be assigned with precision to specific opioid drug-receptor interactions. We administered a set of training doses of ketocyclazocine, morphine, cyclazocine, naloxone and placebo to 10 drug-using volunteers and obtained similarity judgements between each of 2 test doses of the drugs and a training dose. These data were submitted to multidimensional scaling analysis (INDSCAL) using both neighboring cells estimates and root mean square estimates to estimate missing cells in the data matrices. The results of these analyses are convergent, appear valid and indicate that there are three drug dimensions expressed in this data set: morphine versus placebo and naloxone; cyclazocine and ketocyclazocine versus placebo and naloxone; and ketocyclazocine versus cyclazocine. We interpret this result as supporting evidence that in the set of five drugs studied, three subjective states are induced.
阿片类药物对人体的主观和生理作用概况，无法精确地归因于特定的阿片类药物 - 受体相互作用。我们给10名吸毒志愿者施用了一组环唑辛、吗啡、环唑辛、纳洛酮和安慰剂的训练剂量，并获得了每种药物的2个测试剂量与一个训练剂量之间的相似性判断。使用相邻单元格估计和均方根估计对这些数据进行多维标度分析（INDSCAL），以估计数据矩阵中的缺失单元格。这些分析结果是一致的，看起来是有效的，表明该数据集中表达了三个药物维度：吗啡与安慰剂和纳洛酮；环唑辛和环唑辛与安慰剂和纳洛酮；以及环唑辛与环唑辛。我们将这一结果解释为支持性证据，即在研究的五种药物中，诱导出了三种主观状态。
