Xiao Yao, Ma Jian-zhong
Basic Medical of Chinese Medical University, Shenyang, China.
Zhonghua Gan Zang Bing Za Zhi. 2012 Oct;20(10):774-9. doi: 10.3760/cma.j.issn.1007-3418.2012.10.014.
To study the association of genetic polymorphism of glutathione S-transferase (GSTM1 and GSTT1) with susceptibility to primary liver cancer in Chinese.
Literature search of the PubMed, Chinese National Knowledge Infrastructure, and ISI Web of Science databases identified 25 relevant case-control studies of glutathione S-transferase genetic polymorphisms and primary liver cancer, representing a total of 2788 cases and 5548 controls. The extracted data was applied to the RevMan v4.2 software for meta-analysis. Data with significant heterogeneity was assessed by the fixed effects model, otherwise a random effects model was applied. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
The correlation between the GSTM1 and GSTT1 null genotypes and susceptibility to primary liver cancer showed statistical significance (cases: P = 1.8 * 10(-11) and controls: P = 4.6 * 10(-11); Pearson's Chi-squared test). The OR value for GSTM1 was 1.67 (95% CI: 1.39-2.01) and for GSTT1 was 1.59 (95% CI: 1.26-1.96). In the GSTM1-GSTT1 interaction analysis, both GSTM1 and GSTT1 were null genotypes with OR = 3.34 (95% CI: 2.23-5.00), which was higher than the null genotype for either one of them alone and which indicated higher relative susceptibility. Compared with individuals for whom both GSTM1 and GSTT1 were non-null genotypes, the presence of at least one null genotype showed higher risk of primary liver cancer.
The null genotypes of glutathione S-transferase genetic polymorphisms GSTM1 and GSTT1 are risk factors for primary liver cancer respectively, and their associated risk is increased when both are present.
研究谷胱甘肽S-转移酶（GSTM1和GSTT1）基因多态性与中国人原发性肝癌易感性的关系。
通过检索PubMed、中国知网和ISI Web of Science数据库，确定了25项关于谷胱甘肽S-转移酶基因多态性与原发性肝癌的相关病例对照研究，共纳入2788例病例和5548例对照。将提取的数据应用于RevMan v4.2软件进行荟萃分析。对存在显著异质性的数据采用固定效应模型评估，否则采用随机效应模型。计算合并比值比（OR）及95%置信区间（CI）。
GSTM1和GSTT1基因缺失型与原发性肝癌易感性之间的相关性具有统计学意义（病例组：P = 1.8×10⁻¹¹，对照组：P = 4.6×10⁻¹¹；Pearson卡方检验）。GSTM1的OR值为1.67（95%CI：1.39 - 2.01），GSTT1的OR值为1.59（95%CI：1.26 - 1.96）。在GSTM1 - GSTT1相互作用分析中，GSTM1和GSTT1均为基因缺失型时OR = 3.34（95%CI：2.2 – 5.00），高于二者单独存在基因缺失型时的情况，提示相对易感性更高。与GSTM1和GSTT1均为非基因缺失型的个体相比，至少存在一种基因缺失型的个体患原发性肝癌的风险更高。
谷胱甘肽S-转移酶基因多态性GSTM1和GSTT1的基因缺失型分别是原发性肝癌的危险因素，二者同时存在时相关风险增加。
